Arizona has topped 40 points three times and 30 on four other occasions, including the last three in a row. Together with the league's No. 3-ranked defense, the Cardinals (8-2) take a three-game NFC West lead into Sunday's game at San Francisco.
Arizona's third-ranked defense intercepted four of Kaepernick's passes in a 47-7 victory in Week 3, including two returned for touchdowns. Mathieu was responsible for two of those turnovers, and scored on a 33-yard return on San Francisco's second possession.